IMBA Professional Plus - Base Unit

The base unit is the core of IMBA Professional Plus and enables the user to perform basic internal dosimetry calculations. It implements the latest ICRP biokinetic and dosimetric models. Output is both tabular and graphical and special tools enable data transfer between Windows applications. For standard calculations, all of the ICRP default values can be selected from built-in databases at the touch of a button. For more detailed calculations, the user can enter individual parameter values. Calculations are performed 6-10 times faster than in the previous software (IMBA Expert/Professional Series). The product has been extensively quality assured and comes with complete documentation.

The Base Unit includes the capability to:

• Assess an intake from bioassay measurement data;
• Calculate bioassay quantities at different times from a specific intake;
• Calculate equivalent organ doses and effective dose from a single intake.

The IMBA Professional Plus - Base Unit is intended for the user who does not require all of the advanced features provided as modular "Add Ons". For the more advanced user, the various Add Ons provide additional, highly specialised, fully-integrated features, which greatly enhance the software's functionality.

The IMBA Professional Plus - Base Unit enables you to do the following:

• Assess intakes from inhalation, ingestion, injection or transdermal wounds by using bioassay measurement data
• Calculate bioassay quantities as a function of time - implemented quantities are: Whole Body, Lungs, Urine, Faeces, Blood, Thyroid, Liver, User Defined function.
• Calculate equivalent organ doses and effective dose from a single intake.

and includes the following basic features:

• Calculate the best estimate of the amount of intake - from a single exposure event (intake regime), based on the user-specified intake scenario.
• Analyse any of the above types of bioassay measurement - for a given indicator radionuclide.
• Specify the date and time-of-day of each bioassay measurement.
• Specify the collection period for each urine and fecal sample (as a fraction of a day).
• Define all absorption parameter values and aerosol characteristics - or select the absorption parameters from a built-in database of ICRP-recommended values.
• Define bioassay retention functions - or select these from a database of ICRP-recommended values.
• Toggle between ICRP60/68, ICRP26, or 10 CFR 835 tissue weighting factors and remainder tissue rules.
• Enter user specified particle transport rates (in the respiratory tract) - or use ICRP defaults - and perform calculations for both Reference Worker (light activity) and heavy activity.
• Apply built-in ICRP biokinetic models for each element - or specify user-defined models.
• Apply the built-in ICRP Publication 38 radiation database - and view complete decay chains and nuclear data on-screen.
• The ability to deal with chelated intakes – by marking and excluding “treatment-enhanced” excretion data from the intake assessment.
• Exclude unreliable data points from the fitting process - but not from the data record - and mark these as such in the associated graph of the data.
• Apply the maximum likelihood fitting method - to deal with:
  1. data recorded as “less than the limit of detection” (< LOD);
  2. explicit error on each data point;
  3. normal or lognormal error distributions;
  4. up to 200 data points.
• Calculate the committed equivalent dose to each organ or tissue - and the effective dose - from an indicator radionuclide.
• Toggle between pCi and Bq activity units.
• Calculate bioassay quantities over specified time intervals - for design of future monitoring programs.
• Display bioassay data (with error bars and the fitted bioassay function) graphically on-screen - in multiple windows.
• Interchangeably display tables of bioassay data and predicted bioassay quantities with graphs of the same quantities.
• Use built-in, highly flexible, graphical and spreadsheet tools to facilitate setting up your graphs and data entry.
• Import/export bioassay data between IMBA Expert™ and a Windows® spreadsheet.
• Copy data to-and-from spreadsheets and other Windows® applications.
• Copy data to-and-from an ASCII file.
• Create a comprehensive report file containing administrative details, all case parameter assumptions, and the calculated results.
• Save all assumptions, parameter values and results to a single, nameable data file – which can be read in to any version of IMBA Expert™, running on any compatible PC computer system.
• Save and reload all assumed parameter values and calculated results for a particular case study in a comprehensive parameter file.